How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass

How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass
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Glucagon-like peptide-1 (GLP-1) drugs (1, 2, 3, 4), more commonly known as semaglutide or Ozempic, Wegovy, and Rybelsus, were originally prescribed for diabetes but have become very popular regular white/yellow fat (body fat/adipose tissue) weight loss tools. Two of the many reported negative side effects are Ozempic face (5) and muscle mass (lean body mass) loss. Do GLP-1 weight loss drugs like Ozempic cause muscle mass loss?

Body Composition - How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass - Image by <a href="https://pixabay.com/users/massagenerds-5254990/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=2277447">Ryan Hoyme</a> from <a href="https://pixabay.com//?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=2277447">Pixabay</a>

Body composition is currently scientifically/medically defined by lean body mass (LBM)(6, 7, 8, 9, 10) — sometimes referred to as fat-free mass (FFM) — versus body fat (adipose tissue/regular white/yellow fat)(11). Lean body mass includes muscle tissue (skeletal muscle, smooth muscle, and cardiac muscle) along with organs, ligaments, tendons, bones, and bodily fluid. To calculate lean body mass you subtract total body fat from total body weight.

Although no official standard currently exists to accurately calculate total body fat, popular methods (12) include body circumference measurements (13), hip-to-waist ratio (14),  and body fat percentage calculations (15). However, no body fat calculation method accounts for genetic skinny fat tissue (thin fat, cellulite)(16), and the only technology that currently exists to determine skinny fat tissue is the Scientific Body Type One Quiz (17). Just as no official standard exists to accurately calculate muscle mass (18, 19). Thus, body fat and lean body mass calculations are not particularly accurate and are more of a guideline.

How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass

Yet, the vast majority of scientific studies (20, 21, 22) use known inaccurate body fat and lean body mass methods when attempting to determine how much GLP-1 weight loss drugs like Ozempic affect muscle mass loss. Some of the conclusions indicate high muscle mass loss, with estimates ranging from 30% to 60% (20, 23, 24, 25, 26). While in seeming contradiction, one American Heart Association Journal study generally concluded (27) that “GLP-1 RA treatments appear to be adaptive [a physiologic response to weight loss maintaining or minimally affecting muscle health or function].”

The fact is, the vast majority (if not all) of studies don’t know how much muscle mass each participant had before they lost weight using a GLP-1 drug. Therefore, we do not know if any participant did not have the muscle mass to begin with, and, instead, many likely have genetic skinny fat tissue where they genetically should have muscle mass. If they do, indeed, have genetic skinny fat tissue where they should genetically have default muscle/mass tissue, then they never had the default genetic muscle tissue to start.

Weight Loss & Unique Genetic Body Composition

Did 27-year-old Research Participant 1053’s (28) weight loss cause them to lose muscle mass? Or is their unique genetic body composition the reason why they did not have the genetic muscle/mass tissue from the beginning?

How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass - Research Participant 1053

They started at an obese BMI of 32.1. The widespread skinny fat tissue — thin fat and cellulite — is clear and obvious. So is the lack of genetic default muscle tissue.

They safely lost 34 pounds to get down to an overweight BMI of 26.3. The abundant skinny fat tissue and lack of muscle tissue remain clear and obvious in all the same places. They have 8 pounds to lose to get to within safe BMI (18.5 to 24.99). But they have obvious skinny fat tissue where they should have genetic default muscle mass, as per the Standard Body Type One (BT1)(29, 30, 31).

Standard Body Type One (BT1) - How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass

All 600+ of those supposed genetically developed muscles are not going to magically appear/exist on 1053’s body when they lose those remaining 8 pounds, or 20 pounds, or even all the way down to 18.5 BMI. Genetics, i.e. their unique genetic body composition matters.

Real Skinny Fat Tissue

Here is 23-year-old Research Participant 1170 (32). They started within safe BMI at 24.6. The skinny fat tissue  — cellulite and thin fat — is obvious and clear, as is the normal weight obesity and lack of genetic default muscle/mass. They safely lost even more regular fat weight and dropped deeper within safe BMi to 21.3, yet, the genetic skinny fat tissue relative to a lack of default genetic muscle tissue clearly and obviously remain, in all the same places. Genetics.

RP 1170 Weight Loss Before and After - How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass

They are not a Standard Body Type One (BT1) — they are a Body Type Three (BT3)(33) due to their unique genetic body composition.

RP1170 Thin Fat and Cellulite Skinny Fat

Here is Joe Rogan when he was fat-shamed on social media:

Joe Rogan Fat Shamed
The Sun, UK Edition – Joe Rogan shows off dramatic body transformation after being fat-shamed

He is an obvious and clear Standard Body Type One (BT1) with all 600+ muscles developed. Even when he is fat (too much regular white/yellow body fat) you can clearly see his abdominal muscles et al, just like the Standard BT1 image above.

Science and Technology – How Skinny Fat Affects GLP-1 (Ozempic) Weight Loss & Muscle Mass

Human science and technology are young and evolving. Until skinny fat science reaches the mainstream, and healthcare, medical professionals, and people, in general, better understand unique genetic body composition as a whole, the inaccuracy and confusion will continue. As skinny fat science — science overall —  improves, technologies will adapt to accurately account for, measure, and determine the full Scientific Body Type Quiz (Official)spectrum of body composition variables including skinny fat tissue. And no less than how GLP-1’s like Ozempic effect weight loss and muscle mass will become more clear.

The Scientific Health Quizzes (34) are the first step in this evolution. The Science Body Type Quiz (17) is the debut technology to determine skinny fat tissue — with an AI version coming soon. It is complemented by the Scientific Metabolism Quiz (35), Scientific Diet Quiz (36), Scientific Exercise Quiz (37), Scientific Lifestyle Quiz (38), and Scientific Total Health Quiz (39). They all use the very latest comprehensive science in proprietary algorithms to accurately calculate each person’s unique metrics safely, securely, and privately.

Scientific Health Quizzes - Body Composition, Metabolism, Diet, Exercise, Lifestyle, Total Health

No personal information is required; you can use a Pen Name and no face is used in the images. The only thing required is a valid email to sign up for a free account.

 

Skinny Fat Body Type Science


References
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